A deconstruction-reconstruction strategy for pyrimidine diversification. (https://pubmed.ncbi.nlm.nih.gov/38697196/)

These scientists wanted to find new ways to make different kinds of molecules that could be used in medicines and pesticides. They focused on a specific type of molecule called pyrimidines, which have a nitrogen atom in their structure. They discovered a way to change these pyrimidines into other types of molecules with nitrogen in them. This new method allowed them to create a building block that could be used to make even more different kinds of molecules, like azoles. By using this approach, they were able to make complex molecules that would have been difficult to make using other methods. They believe that this strategy can be applied to making other types of molecules in the future.

Uhlenbruck BJH., Josephitis CM., de Lescure L., Paton RS., McNally A. A deconstruction-reconstruction strategy for pyrimidine diversification. Nature. 2024 May 2. doi: 10.1038/s41586-024-07474-1.