A glycolytic metabolite that drives BRCA2 haploinsufficiency. (https://pubmed.ncbi.nlm.nih.gov/38670069/)

These scientists wanted to understand how some types of cancer cells change the way they use energy to grow and survive. They found that a specific molecule called methylglyoxal can cause changes in a protein called BRCA2, which is important for repairing damaged cells. When BRCA2 is affected by methylglyoxal, it doesn't work as well as it should, which can lead to problems in the cells that may contribute to cancer growth. This discovery helps us learn more about how cancer cells function and may lead to new ways to treat cancer in the future.

Jiang P. A glycolytic metabolite that drives BRCA2 haploinsufficiency. Cell. 2024 Apr 25;187(9):2124-2126. doi: 10.1016/j.cell.2024.03.028.