FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. (https://pubmed.ncbi.nlm.nih.gov/38701783/)
These scientists looked at a gene called FLT3LG that is important for the development of certain types of immune cells in mice. They found three people who had a specific change in this gene that made it not work properly. These people had a history of getting sick often, especially with skin warts.
When the scientists looked at the bone marrow (the part of our body that makes blood cells) of these patients, they found that it was not making enough of the cells needed for the immune system to work well. Some types of immune cells, like B cells and dendritic cells, were particularly low in these patients.
The scientists also checked the blood of these patients and found that some types of immune cells were lower than normal, while others were not as affected. They found that this gene is important for the development of certain immune cells in both mice and humans, but there are some differences between the two species.
Overall, this study showed that the FLT3LG gene is important for the development of certain immune cells in humans, and when it doesn't work properly, it can lead to problems with the immune system and make people more prone to infections.
Momenilandi M., Levy R., Sobrino S., Li J., Lagresle-Peyrou C., Esmaeilzadeh H., Fayand A., Le Floc'h C., Guerin A., Mina ED., Shearer D., Delmonte OM., Yatim A., Mulder K., Mancini M., Rinchai D., Denis A., Neehus AL., Balogh K., Brendle S., Rokni-Zadeh H., Changi-Ashtiani M., Seeleuthner Y., Deswarte C., Bessot B., Cremades C., Materna M., Cederholm A., Ogishi M., Philippot Q., Beganovic O., Ackermann M., Wuyts M., Khan T., Fouere S., Herms F., Chanal J., Palterer B., Bruneau J., Molina TJ., Leclerc-Mercier S., Pretet JL., Youssefian L., Vahidnezhad H., Parvaneh N., Claeys KG., Schrijvers R., Luka M., Perot P., Fourgeaud J., Nourrisson C., Poirier P., Jouanguy E., Boisson-Dupuis S., Bustamante J., Notarangelo LD., Christensen N., Landegren N., Abel L., Marr N., Six E., Langlais D., Waterboer T., Ginhoux F., Ma CS., Tangye SG., Meyts I., Lachmann N., Hu J., Shahrooei M., Bossuyt X., Casanova JL., Beziat V. FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Cell. 2024 May 23;187(11):2817-2837.e31. doi: 10.1016/j.cell.2024.04.009. Epub 2024 May 3.