Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties. (https://pubmed.ncbi.nlm.nih.gov/38626770/)

These scientists wanted to understand how a process called ubiquitylation works in cells. Ubiquitylation is like a tag that proteins in our cells can have, and it helps control many important functions. The scientists studied how often and how quickly these tags are added and removed from proteins.

They found that the tags are added to different proteins at different rates, with some proteins having a lot of tags and others having very few. They also discovered that the tags are removed more quickly from proteins in certain parts of the cell compared to others.

One interesting thing they found was that there is a mechanism in cells that can quickly remove these tags from certain enzymes, which helps protect the enzymes from getting too many tags.

Overall, this study gives us a better understanding of how ubiquitylation works in cells and how it helps regulate important processes.

Prus G., Satpathy S., Weinert BT., Narita T., Choudhary C. Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties. Cell. 2024 May 23;187(11):2875-2892.e21. doi: 10.1016/j.cell.2024.03.024. Epub 2024 Apr 15.