Oxygen isotope ensemble reveals Earth's seawater, temperature, and carbon cycle history. (link)

A deep reservoir for hydrogen drives intense degassing in the Bulqize ophiolite. (link)

Gut-liver axis calibrates intestinal stem cell fitness. (link)

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. (link)

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage. (link)

A novel antibiotic class targeting the lipopolysaccharide transporter. (link)

Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. (link)

Base-editing mutagenesis maps alleles to tune human T cell functions. (link)

Through the looking glass: An adventure into the metastable world of the bacterial cytoplasm. (link)

PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome. (link)

Gut complement induced by the microbiota combats pathogens and spares commensals. (link)

First step taken toward artificial plant genome. (link)

Cell surface RNAs control neutrophil recruitment. (link)

Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity. (link)

A tridimensional atlas of the developing human head. (link)

Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. (link)

APOE3ch alters microglial response and suppresses Abeta-induced tau seeding and spread. (link)

Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics. (link)

Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. (link)

An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling. (link)

Direct observation of a condensate effect on super-enhancer controlled gene bursting. (link)

Inherited blood cancer predisposition through altered transcription elongation. (link)

Degradation trumps mutations in cancer. (link)

Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition. (link)

Cytoneme signaling provides essential contributions to mammalian tissue patterning. (link)

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. (link)

Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. (link)

N(1)-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. (link)

Cell-type-directed design of synthetic enhancers. (link)

Discovery of a structural class of antibiotics with explainable deep learning. (link)

Population genomics of post-glacial western Eurasia. (link)

Disease-specific tau filaments assemble via polymorphic intermediates. (link)

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA. (link)

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels. (link)

Extracellular pectin-RALF phase separation mediates FERONIA global signaling function. (link)

Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. (link)

Cell at fifty. (link)

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma. (link)

Microbial transmission in the social microbiome and host health and disease. (link)

Bispecific dendritic-T cell engager potentiates anti-tumor immunity. (link)

Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies. (link)

The innovation menagerie: New institutional structures are expanding horizons for early-stage research. (link)

Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques. (link)

A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design. (link)

Machine learning interpretable models of cell mechanics from protein images. (link)

SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency. (link)

Human fetal brain self-organizes into long-term expanding organoids. (link)

Constructing human neural circuits in living systems by transplantation. (link)

Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants. (link)

Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. (link)