Sister chromatid cohesion establishment during DNA replication termination. (https://pubmed.ncbi.nlm.nih.gov/38484038/)

These scientists wanted to understand how a special group of molecules called cohesin helps keep the two copies of DNA together when a cell makes a new copy of itself. They used a very powerful microscope to watch what happens when the cell copies its DNA.

They found out that instead of staying in one place, the cohesin molecules move along with the part of the cell that makes the new copy of DNA. When two copies of DNA come together, the cohesin molecules help keep them stuck together.

They also discovered that when the DNA copying process is finished, some other molecules help remove the parts that copy DNA, but the cohesin molecules stay behind to make sure the two DNA copies are still connected.

This study helps us understand better how cells make sure their DNA copies are kept together properly, which is important for the cell to work correctly.

Cameron G., Gruszka DT., Gruar R., Xie S., Kaya C., Nasmyth KA., Baxter J., Srinivasan M., Yardimci H. Sister chromatid cohesion establishment during DNA replication termination. Science. 2024 Apr 5;384(6691):119-124. doi: 10.1126/science.adf0224. Epub 2024 Mar 14.