Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle. (https://pubmed.ncbi.nlm.nih.gov/38452761/)

These scientists wanted to understand how cells change during the different stages of their life cycle. They used special computer programs called convolutional neural networks to look at pictures of millions of yeast cells under a microscope. These pictures showed them the different proteins inside the cells and where they were located.

The scientists found that about a quarter of all the proteins in the cells changed during the cell cycle, which is the process of a cell growing and dividing. Some proteins moved to different parts of the cell, while others changed in how much of them were present. They discovered that proteins are usually controlled in either their location or their amount, but not both at the same time.

The changes in protein amount were mostly important for controlling the cell cycle, while changes in protein location helped the cell carry out its growth and division tasks. This study helps us learn more about how cells work and grow, which is important for understanding how living things function.

Litsios A., Grys BT., Kraus OZ., Friesen H., Ross C., Masinas MPD., Forster DT., Couvillion MT., Timmermann S., Billmann M., Myers C., Johnsson N., Churchman LS., Boone C., Andrews BJ. Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle. Cell. 2024 Mar 14;187(6):1490-1507.e21. doi: 10.1016/j.cell.2024.02.014. Epub 2024 Mar 6.