Proteomics: A new dimension to decode small cell lung cancer. (https://pubmed.ncbi.nlm.nih.gov/38181738/)

These scientists wanted to understand more about a type of cancer called small cell lung cancer (SCLC). They knew that this type of cancer is very difficult to treat, so they wanted to learn more about how it works.

To do this, the scientists studied samples of SCLC tumors that had been removed from patients. They used a special technique called proteomics and phosphoproteomics to look at the different proteins and molecules inside the tumors.

By doing this, they were able to create a map of all the proteins and molecules in the tumors. This map helped them see how the cancer cells were different from normal cells.

The scientists also found some new weaknesses in the cancer cells that could be targeted with treatments. This means that they discovered new ways to attack the cancer and hopefully find better ways to treat it in the future.

Chen H., Drapkin BJ., Minna JD. Proteomics: A new dimension to decode small cell lung cancer. Cell. 2024 Jan 4;187(1):14-16. doi: 10.1016/j.cell.2023.11.042.