Automatic cell-type harmonization and integration across Human Cell Atlas datasets. (https://pubmed.ncbi.nlm.nih.gov/38134877/)

These scientists wanted to create a map of all the different types of cells in the human body. They made a special tool called CellHint to help them do this. CellHint can look at the genetic information of cells and figure out which cells are similar to each other.

The scientists used CellHint to study cells from different parts of the body, like the immune system and the lungs. They found that CellHint could accurately tell them which cells were similar and which were different. It even helped them discover new relationships between healthy and diseased lung cells.

The scientists also used CellHint to study cells from the hippocampus, which is a part of the brain. They found some new types of cells that hadn't been discovered before.

Finally, the scientists used CellHint to study cells from many different tissues in the body. They created a big database with millions of cells and used special computer programs to automatically label the cells based on their genetic information.

By using CellHint, these scientists made important discoveries about the different types of cells in our bodies and how they are related to each other.

Xu C., Prete M., Webb S., Jardine L., Stewart BJ., Hoo R., He P., Meyer KB., Teichmann SA. Automatic cell-type harmonization and integration across Human Cell Atlas datasets. Cell. 2023 Dec 21;186(26):5876-5891.e20. doi: 10.1016/j.cell.2023.11.026.