Automated model building and protein identification in cryo-EM maps. (https://pubmed.ncbi.nlm.nih.gov/38408488/)

These scientists created a special computer program called ModelAngelo to help them build models of tiny molecules called proteins and nucleotides. Building these models manually is very hard work and requires a lot of expertise. But with ModelAngelo, the computer can do it faster and just as well as humans.

The program uses information from the cryo-EM maps (which show how the molecules look) and information about the protein's structure and sequence to figure out how the molecules are put together. It's like a puzzle for the computer to solve. ModelAngelo is so good at this that it can even identify proteins with unknown sequences better than humans can.

By using ModelAngelo, scientists can speed up their research and make it more accurate. It helps them understand how these tiny molecules work and how they are built.

Jamali K., Kall L., Zhang R., Brown A., Kimanius D., Scheres SHW. Automated model building and protein identification in cryo-EM maps. Nature. 2024 Feb 26. doi: 10.1038/s41586-024-07215-4.