Spatial proteomics in neurons at single-protein resolution. (https://pubmed.ncbi.nlm.nih.gov/38552614/)

These scientists wanted to learn more about the different parts of cells and how they interact with each other. They used a special kind of microscope called super-resolution microscopy to see things that are very tiny. However, this microscope could only show a few things at a time. So, the scientists came up with a new method called SUM-PAINT. This method allowed them to see many different things all at once, like looking at a lot of different colors in a picture.

They used SUM-PAINT to look at 30 different parts of cells in neurons, which are cells in our brains. By doing this, they found out that there are different kinds of connections between neurons that they didn't know about before. This discovery helps other scientists understand more about how our brains work.

The scientists also made it easier for other researchers to use their method and analyze the data they collected. This means that more scientists can now study cells in great detail and learn new things about how our bodies function.

Unterauer EM., Shetab Boushehri S., Jevdokimenko K., Masullo LA., Ganji M., Sograte-Idrissi S., Kowalewski R., Strauss S., Reinhardt SCM., Perovic A., Marr C., Opazo F., Fornasiero EF., Jungmann R. Spatial proteomics in neurons at single-protein resolution. Cell. 2024 Mar 28;187(7):1785-1800.e16. doi: 10.1016/j.cell.2024.02.045.