Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain. (https://pubmed.ncbi.nlm.nih.gov/38600385/)

These scientists wanted to understand more about how different types of brain cells are related to each other in the human brain. They used a special technique called cell-type-specific mosaic variant barcode analysis to look at the patterns of variation in brain cells from different parts of the brain. They studied brain samples from four different parts of the brain from two different people.

By analyzing the patterns of variation in the brain cells, the scientists were able to see how different types of neurons are related to each other and how they develop in the brain. They found that certain types of neurons in the hippocampus, neocortex, and basal ganglia have different patterns of development and lineage relationships.

The scientists also looked at the genetic and molecular characteristics of these cells to see how they are related to each other at a more detailed level. They discovered that some inhibitory neurons in the brain have a common origin with excitatory neurons in a specific part of the brain.

Overall, this study helped the scientists uncover important information about how different types of brain cells develop and are related to each other in the human brain.

Chung C., Yang X., Hevner RF., Kennedy K., Vong KI., Liu Y., Patel A., Nedunuri R., Barton ST., Noel G., Barrows C., Stanley V., Mittal S., Breuss MW., Schlachetzki JCM., Kingsmore SF., Gleeson JG. Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain. Nature. 2024 May;629(8011):384-392. doi: 10.1038/s41586-024-07292-5. Epub 2024 Apr 10.