Copper-catalysed dehydrogenation or lactonization of C(sp(3))-H bonds. (https://pubmed.ncbi.nlm.nih.gov/38547926/)

These scientists wanted to find a new way to make certain chemicals by using a special type of catalyst called Cu(I). They discovered a method to change the structure of molecules by removing certain parts of them and adding new ones in a very precise way. They found that by using a specific type of molecule called N-methoxyamides, they could make these changes without creating a lot of waste. This new method allows them to modify different types of molecules, including ones used in medicines and natural products, without damaging their delicate structures. This discovery is important because it makes the process of creating new chemicals more efficient and environmentally friendly.

Zhou S., Zhang ZJ., Yu JQ. Copper-catalysed dehydrogenation or lactonization of C(sp(3))-H bonds. Nature. 2024 May;629(8011):363-369. doi: 10.1038/s41586-024-07341-z. Epub 2024 Mar 28.