Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology. (https://pubmed.ncbi.nlm.nih.gov/38513664/)

These scientists wanted to understand more about a disease called multiple sclerosis (MS), which affects the brain and spinal cord. They studied how the disease progresses over time and in different parts of the body using mice that had a similar condition to MS.

To do this, the scientists looked at individual cells in the areas affected by the disease using a special technique called in situ sequencing (ISS). This allowed them to see how different types of cells were behaving in the body during the disease.

They found that certain cells called disease-associated glia were involved in the progression of the disease, and that these cells appeared and disappeared as the disease got worse or better. By studying both mice and human samples, the scientists were able to create a detailed map of how the disease affects the cells in the body at a very tiny level.

Overall, this study helped the scientists understand more about how MS develops and progresses, which could help in finding better treatments for people with this disease.

Kukanja P., Langseth CM., Rubio Rodriguez-Kirby LA., Agirre E., Zheng C., Raman A., Yokota C., Avenel C., Tiklova K., Guerreiro-Cacais AO., Olsson T., Hilscher MM., Nilsson M., Castelo-Branco G. Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology. Cell. 2024 Apr 11;187(8):1990-2009.e19. doi: 10.1016/j.cell.2024.02.030. Epub 2024 Mar 20.