Multisensory gamma stimulation promotes glymphatic clearance of amyloid. (https://pubmed.ncbi.nlm.nih.gov/38418876/)

These scientists wanted to understand how the brain removes waste and how this process can be improved to help with Alzheimer's disease. They did experiments using mice that have a disease similar to Alzheimer's.

First, they used a special type of stimulation called multisensory gamma stimulation on the brains of these mice. This stimulation helped to increase the flow of fluid in the brain, which is important for removing waste. They found that this stimulation caused certain cells in the brain to change and allowed more fluid to move around.

The scientists also discovered that a specific type of cell in the brain, called vasoactive intestinal peptide interneurons, plays a role in helping the brain clear out waste. By studying these cells, the scientists learned more about how the brain gets rid of harmful substances like amyloid, which is a key factor in Alzheimer's disease.

Overall, these scientists found new ways to help the brain clean itself and remove harmful substances, which could be important for finding new treatments for Alzheimer's disease.

Murdock MH., Yang CY., Sun N., Pao PC., Blanco-Duque C., Kahn MC., Kim T., Lavoie NS., Victor MB., Islam MR., Galiana F., Leary N., Wang S., Bubnys A., Ma E., Akay LA., Sneve M., Qian Y., Lai C., McCarthy MM., Kopell N., Kellis M., Piatkevich KD., Boyden ES., Tsai LH. Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature. 2024 Feb 28. doi: 10.1038/s41586-024-07132-6.