Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. (https://pubmed.ncbi.nlm.nih.gov/38714197/)

These scientists wanted to learn more about the different types of cells in our bones that help create new blood cells. To do this, they used a special technique called single-cell RNA sequencing to study over 29,000 non-blood cells and found nine different types. They also looked at over 53,000 blood cells and predicted how they interact with the non-blood cells.

Then, they used another method called CODEX to look at the location of over 1.2 million cells in the bone marrow. By combining the data from both techniques, they were able to see how different cells communicate with each other based on where they are in the bone marrow.

The scientists discovered that certain areas in the bone marrow have more oxygen and are important for making certain types of blood cells. They also found that early blood cell stem cells like to hang out near fat cells.

By using their data, they were able to identify new patterns in bone marrow samples from patients with a type of blood cancer called acute myeloid leukemia. This study helps us understand how different cells work together in our bones to make new blood cells.

Bandyopadhyay S., Duffy MP., Ahn KJ., Sussman JH., Pang M., Smith D., Duncan G., Zhang I., Huang J., Lin Y., Xiong B., Imtiaz T., Chen CH., Thadi A., Chen C., Xu J., Reichart M., Martinez Z., Diorio C., Chen C., Pillai V., Snaith O., Oldridge D., Bhattacharyya S., Maillard I., Carroll M., Nelson C., Qin L., Tan K. Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell. 2024 May 2:S0092-8674(24)00408-2. doi: 10.1016/j.cell.2024.04.013.