Degradation trumps mutations in cancer. (https://pubmed.ncbi.nlm.nih.gov/38301021/)

These scientists wanted to find a way to make medicine work better against certain diseases. They discovered that sometimes, the medicine stops working because the bad cells in our bodies learn how to protect themselves from the medicine. So, the scientists came up with a clever idea to trick these bad cells.

They made a plan to redirect some special proteins in our bodies. These proteins are like tiny machines that help our cells work properly. The scientists found a way to change the instructions of these proteins so they would attack the bad cells instead of helping them.

To test their plan, the scientists took some cells that had become resistant to medicine. They used their special method to redirect the proteins towards these cells. And guess what? It worked! The proteins started attacking the bad cells and made the medicine effective again.

This study shows that by redirecting these proteins, we can overcome the problem of medicine not working anymore. It's like finding a secret way to make the medicine win the fight against the bad cells. This discovery can help many people who are sick and need medicine to get better.

Davis RE., Westin JR. Degradation trumps mutations in cancer. Science. 2024 Feb 2;383(6682):480-481. doi: 10.1126/science.adn4945. Epub 2024 Feb 1.