Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques. (https://pubmed.ncbi.nlm.nih.gov/38422185/)

These scientists wanted to find a way to help monkeys infected with a virus similar to HIV. They gave the monkeys a combination of a medicine called N-803 and special antibodies that can fight the virus. Even though the treatment didn't completely get rid of the virus, it helped the monkeys control the virus better when they stopped taking their regular medicine. They found that around 70% of the monkeys were able to keep the virus under control even after stopping their regular medicine. The scientists think that this treatment helped the monkeys' immune system fight the virus better. This study shows that we might not need to completely get rid of the virus to help people with HIV live healthier lives.

Lim SY., Lee J., Osuna CE., Vikhe P., Schalk DR., Chen E., Fray E., Kumar M., Schultz-Darken N., Rakasz E., Capuano S., Ladd RA., Gil HM., Evans DT., Jeng EK., Seaman M., Martin M., Van Dorp C., Perelson AS., Wong HC., Siliciano JD., Siliciano R., Safrit JT., Nixon DF., Soon-Shiong P., Nussenzweig M., Whitney JB. Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques. Science. 2024 Mar 8;383(6687):1104-1111. doi: 10.1126/science.adf7966. Epub 2024 Feb 29.