Multimodal decoding of human liver regeneration. (https://pubmed.ncbi.nlm.nih.gov/38693268/)

These scientists wanted to learn more about how the liver can heal itself after being damaged. They studied liver samples from healthy people and people with a serious condition called acute liver failure. They looked at the individual cells in the liver to see how they work together to repair the damage.

They discovered a special group of liver cells that can move around and help fix the liver when it's injured. They also found that these cells help close up the damaged area before other liver cells start growing to replace the damaged tissue.

By studying how these cells move and work together, the scientists hope to find new ways to help the liver heal faster and better when it's been hurt. This could lead to new treatments that help people with liver problems get better more quickly.

Matchett KP., Wilson-Kanamori JR., Portman JR., Kapourani CA., Fercoq F., May S., Zajdel E., Beltran M., Sutherland EF., Mackey JBG., Brice M., Wilson GC., Wallace SJ., Kitto L., Younger NT., Dobie R., Mole DJ., Oniscu GC., Wigmore SJ., Ramachandran P., Vallejos CA., Carragher NO., Saeidinejad MM., Quaglia A., Jalan R., Simpson KJ., Kendall TJ., Rule JA., Lee WM., Hoare M., Weston CJ., Marioni JC., Teichmann SA., Bird TG., Carlin LM., Henderson NC. Multimodal decoding of human liver regeneration. Nature. 2024 May 1. doi: 10.1038/s41586-024-07376-2.