An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. (https://pubmed.ncbi.nlm.nih.gov/38386756/)

These scientists wanted to understand the structures of certain chemicals called securines and securamines, which are found in nature and have some special properties. These chemicals have complex structures that make them hard to recreate in a lab. So, the scientists developed a new way to make these chemicals in the lab by putting different parts together like building blocks.

They used a method called oxidative photocyclizations to help create these chemicals. After many steps and purifications, they were able to make the chemicals they were studying. They also used a special technique called microcrystal electron diffraction to look closely at one of the chemicals they made and understand its structure better.

By making these chemicals in the lab, the scientists can now study them more closely and learn more about how they work and what they can be used for.

Alexander BW., Bartfield NM., Gupta V., Mercado BQ., Del Campo M., Herzon SB. An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. Science. 2024 Feb 23;383(6685):849-854. doi: 10.1126/science.adl6163. Epub 2024 Feb 22.