Computationally restoring the potency of a clinical antibody against Omicron. (https://pubmed.ncbi.nlm.nih.gov/38720086/)

These scientists wanted to make a special antibody that could fight against different versions of the COVID-19 virus, including the Omicron and Delta variants. They used a computer to design a new antibody called 2130-1-0114-112. This new antibody was able to work against the Omicron and Delta variants and was even more powerful than the previous one. They tested this new antibody in the lab and found that it could protect against different strains of the virus. By using this computer-based method, they were able to quickly create a strong antibody that could help fight against the virus and its different versions.

Desautels TA., Arrildt KT., Zemla AT., Lau EY., Zhu F., Ricci D., Cronin S., Zost SJ., Binshtein E., Scheaffer SM., Dadonaite B., Petersen BK., Engdahl TB., Chen E., Handal LS., Hall L., Goforth JW., Vashchenko D., Nguyen S., Weilhammer DR., Lo JK., Rubinfeld B., Saada EA., Weisenberger T., Lee TH., Whitener B., Case JB., Ladd A., Silva MS., Haluska RM., Grzesiak EA., Earnhart CG., Hopkins S., Bates TW., Thackray LB., Segelke BW., Lillo AM., Sundaram S., Bloom JD., Diamond MS., Crowe JE Jr., Carnahan RH., Faissol DM. Computationally restoring the potency of a clinical antibody against Omicron. Nature. 2024 May;629(8013):878-885. doi: 10.1038/s41586-024-07385-1. Epub 2024 May 8.