Genetic determinants of micronucleus formation in vivo. (https://pubmed.ncbi.nlm.nih.gov/38355793/)

These scientists wanted to understand how DNA damage can cause problems in cells. They looked at 997 different types of mice to see which genes are important for keeping DNA safe. They found 145 genes that can either make the problem worse or help fix it. One gene called Dscc1 was especially important and when it wasn't working right, the cells had a lot of issues. They also found that SIRT1, another gene, could help fix the problems caused by Dscc1 not working. This study helps us learn more about how cells stay healthy and how we can use this information to help people with diseases related to DNA damage.

Adams DJ., Barlas B., McIntyre RE., Salguero I., van der Weyden L., Barros A., Vicente JR., Karimpour N., Haider A., Ranzani M., Turner G., Thompson NA., Harle V., Olvera-Leon R., Robles-Espinoza CD., Speak AO., Geisler N., Weninger WJ., Geyer SH., Hewinson J., Karp NA., Fu B., Yang F., Kozik Z., Choudhary J., Yu L., van Ruiten MS., Rowland BD., Lelliott CJ., Del Castillo Velasco-Herrera M., Verstraten R., Bruckner L., Henssen AG., Rooimans MA., de Lange J., Mohun TJ., Arends MJ., Kentistou KA., Coelho PA., Zhao Y., Zecchini H., Perry JRB., Jackson SP., Balmus G. Genetic determinants of micronucleus formation in vivo. Nature. 2024 Feb 14. doi: 10.1038/s41586-023-07009-0.