Couple-close construction of polycyclic rings from diradicals. (https://pubmed.ncbi.nlm.nih.gov/38480891/)

These scientists wanted to create new molecules that could be used in medicine. They found that a certain type of molecule called heteroarenes, which are found in many bioactive compounds, have some really good properties. However, making these molecules in the lab is usually difficult and time-consuming.

So, the scientists came up with a new way to make these molecules more easily. They used a special method called metallaphotoredox C(sp(2))-C(sp(3)) cross-coupling along with Minisci-type radical cyclization. This method allowed them to combine different chemicals together to create new molecules with unique structures.

By using this new approach, the scientists were able to make a variety of different molecules that are important for medicine much faster and more efficiently. This means that in the future, we might have new medicines that are easier to make and could help more people.

Long A., Oswood CJ., Kelly CB., Bryan MC., MacMillan DWC. Couple-close construction of polycyclic rings from diradicals. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07181-x.