Resilient anatomy and local plasticity of naive and stress haematopoiesis. (https://pubmed.ncbi.nlm.nih.gov/38509363/)

These scientists wanted to understand how our body makes different types of blood cells in response to different situations. They discovered that the bone marrow, which is like a factory for making blood cells, can change how many cells it produces based on what the body needs.

To study this, the scientists used special techniques to look inside mice and see how different types of blood cells are made. They found that in the bone marrow, there are different areas where specific blood cells are produced. They also found that when the body is under stress, such as during an infection or after losing blood, the bone marrow can adjust its production of blood cells to help the body recover.

The scientists learned that different parts of the body respond differently to stress. For example, the leg bone and chest bone may react in opposite ways when the body needs more blood cells. They also found that the skull doesn't make more blood cells when there is bleeding.

Overall, this study helped the scientists understand how our body adapts to different situations by changing the production of blood cells in the bone marrow.

Wu Q., Zhang J., Kumar S., Shen S., Kincaid M., Johnson CB., Zhang YS., Turcotte R., Alt C., Ito K., Homan S., Sherman BE., Shao TY., Slaughter A., Weinhaus B., Song B., Filippi MD., Grimes HL., Lin CP., Ito K., Way SS., Kofron JM., Lucas D. Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024 Mar 20. doi: 10.1038/s41586-024-07186-6.