Aminative Suzuki-Miyaura coupling. (https://pubmed.ncbi.nlm.nih.gov/38422125/)

These scientists found a new way to connect different molecules together in a very special way. They used two common reactions called the Suzuki-Miyaura and Buchwald-Hartwig reactions. Normally, the Suzuki-Miyaura reaction joins carbon atoms together, while the Buchwald-Hartwig reaction joins carbon and nitrogen atoms together.

But these scientists did something really cool - they mixed these two reactions together to create a new process. They found a way to change the products of the Suzuki-Miyaura reaction from just carbon-to-carbon links to carbon-nitrogen-carbon links. This means they were able to connect different molecules in a different way than before.

To make this happen, they used a special combination of chemicals that helped the reactions work really well. They also learned a lot about how these reactions work, which could help them come up with even more ways to connect different molecules together in the future.

Onnuch P., Ramagonolla K., Liu RY. Aminative Suzuki-Miyaura coupling. Science. 2024 Mar;383(6686):1019-1024. doi: 10.1126/science.adl5359. Epub 2024 Feb 29.