Structural insights into vesicular monoamine storage and drug interactions. (https://pubmed.ncbi.nlm.nih.gov/38499039/)

These scientists studied how special molecules called biogenic monoamines are stored and released in our bodies by tiny transporters called vesicular monoamine transporters (VMATs). These molecules are important for our brain, hormones, and immune system functions. The scientists used a powerful microscope to look at the structures of one type of VMAT called VMAT1. They found that VMAT1 can hold onto different types of monoamines like dopamine and serotonin, as well as harmful substances that can damage our nerve cells.

By studying the structures of VMAT1, the scientists discovered how it can switch between different shapes to either hold onto monoamines inside or release them outside the cells. This process helps our bodies keep a balance of these important molecules. The scientists also found that certain drugs can affect how VMAT1 works, which could help in developing new treatments for diseases like Parkinson's and drug addiction.

Overall, this study helps us understand how our bodies store and release important molecules, and how we can use this knowledge to develop better treatments for certain diseases.

Ye J., Chen H., Wang K., Wang Y., Ammerman A., Awasthi S., Xu J., Liu B., Li W. Structural insights into vesicular monoamine storage and drug interactions. Nature. 2024 May;629(8010):235-243. doi: 10.1038/s41586-024-07290-7. Epub 2024 Mar 18.